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ButtonLoadingButtonLoading AboutAbout ATTR-CMUrgencySuspectDetectDiagnostic flowchartAbout ATTR-PNUrgencyAwarenessPartnershipStudy DesignStudy DesignAbout ATTR-PNUrgencyAwarenessPartnershipEfficacy & SafetyPivotal efficacyLong-term survivalSubgroup analysisKey secondary endpointsEarly efficacy measuresSafety profileATTR-PNPivotal efficacyPivotal efficacy ALTLong-term efficacyMutations efficacyLong-term survivalSafety profileDosingATTR-CM dosingATTR-PNPivotal efficacyPivotal efficacy ALTLong-term efficacyMutations efficacyLong-term survivalSafety profileMOD/MOARole of TTRATTR-CM MODATTR-CM MOAATTR-PNATTR-PN MODATTR-PN MOASupport & ResourcesMaterialsVideosATTR-PNATTR-PN MODATTR-PN MOA

Prescribing Information

ATTR-PNATTR-PN MODATTR-PN MOA

Vyndaqel 61mg is indicated for the treatment of wild‑type or hereditary transthyretin amyloidosis in adult patients with cardiomyopathy
(ATTR-CM).1

▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. Refer to section 4.8 of the SmPC for how to report adverse reactions.

Clinical suspicion for ATTR-CM should prompt deeper diagnostic evaluationA diagnostic approach for patients with suspected cardiac amyloidosis that includes testing for monoclonal protein with scintigraphy and/or biopsy1,2 *[99mTc-DPD=99mtechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid]; [99mTc-HMDP=99m-technetium¬-hydroxymethylene diphosphonate]; [99mTc-PYP=99mtechnetium-pyrophosphate]; AL=immunoglobulin light chain amyloid fibril protein; ATTR=transthyretin amyloidosis; ATTR-CM=transthyretin amyloid cardiomyopathy; hATTR-CM=hereditary transthyretin amyloid cardiomyopathy; IFE=immunofixation; IHC=immunohistochemistry; MGUS=monoclonal gammopathy of undetermined significance; SPECT=single-photon emission computed tomography; TTR=transthyretin; wtATTR-CM=wild-type transthyretin amyloid cardiomyopathy.
Explore More ATTR-CM Identification and diagnosis Download Resources ATTR-CM MOD Learn the Mechanism of Disease
References:Maurer MS, Bokhari S, Damy T, et al. Expert consensus recommendations for the suspicion and diagnosis of transthyretin cardiac amyloidosis. Circ Heart Fail. 2019;12(9):e006075. doi:10.1161/CIRCHEARTFAILURE.119.006075Gillmore JD, Maurer MS, Falk RH, et al. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation. 2016;133(24):2404-2412. doi:10.1161/CIRCULATIONAHA.116.021612  VYNDAQEL Prescribing InformationLoadingAbout ATTR-CM

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PP-VYN-IRL-0287. January 2025

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PP-UNP-IRL-0891. February 2025