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AboutCurrent Migraine Treatment LimitationsMechanism of ActionEfficacyStudy DesignsAcute TreatmentPreventive TreatmentSafetyDosingPrescribing InformationSupporting ResourcesPatient Resources
Current Migraine Treatment LimitationsPatients with migraine on average take 3+ medications, and there are limitations to those treatments1–4:About Efficacy5

Approximately 30%-40% of people with migraine are not successfully treated using a triptan, for reasons of insufficient efficacy and/or tolerability

 Durability6

In a review of clinical studies, only 18%-33% of patients achieve sustained freedom from pain at 24 hours, and 20%-34% of patients require rescue medication

 Medication-Overuse Headache7

Frequent use of medication for the acute treatment of migraine attacks can lead to medication-overuse headache (MOH)

 Tolerability8,9

Oral preventive treatments like anticonvulsants and beta-blockers are associated with AEs such as weight gain, fatigue and cognitive issues

 Patient Medication Preference10

In a survey of 372 patients with migraine, more would prefer to take a pill (60.6%) as a preventive treatment than an injection (39.5%).

 Contraindications11

11% of patients with migraine have a history of cardiovascular events that make them unsuitable for triptans

▼This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.

References:Ferrari A, Baraldi C, Licata M, Rustichelli C. Polypharmacy among headache patients: a cross-sectional study. CNS Drugs. 2018;32(6):567-578. Burch R. Preventive migraine treatment. [published correction appears in Continuum I. 2-21;27(5):1494-1495.] Continuum (Minneap Minn). 2021;27(3):613-632. Moreno-Ajona D, Chan C, Villar-Martínez MD, Goadsby PJ. Targeting CGRP and 5-HT1F receptors for the acute therapy of migraine: a literature review. Headache. 2019;59(suppl 2):3-19.Gilmore B, Michael M. Treatment of acute migraine headache. Am Fam Physician. 2011;83(3):271-280. Erratum in: Am Fam Physician. 2011;84(7):738.Leroux E, Buchanan A, Lombard L, et al. Evaluation of patients with insufficient efficacy and/or tolerability to triptans for the acute treatment of migraine: a systematic literature review. Adv Ther. 2020;37(12):4765-4796.Cameron C, Kelly S, Hsieh SC, et al. Triptans in the acute treatment of migraine: a systematic review and network meta-analysis. Headache. 2015;55(Suppl 4):221-235.VYDURA (rimegepant) Summary of Product Characteristics.Silberstein SD, Holland S, Freitag F, et al. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society [published correction appears in Neurology. 2013;80(9):871]. Neurology. 2012;78(17):1337-1345.Croop R, Lipton RB, Kudrow D, et al. Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo controlled trial. Lancet. 2021;397(10268):51-60.Mitsikostas DD, Belesioti I, Arvaniti C, et al. Patients’ preferences for headache acute and preventive treatment. J Headache Pain. 2017;18(1):102.Lipton RB, Buse DC, Serrano D, Holland S, Reed ML. Examination of unmet treatment needs among persons with episodic migraine: results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache. 2013;53(8):1300-1311.

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