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Mechanism of Action  Safety & Tolerability

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Dosing Dosing Dosing Information Dose Adjustments Drug Interactions Efficacy & Trial Design Efficacy Efficacy Trial Design Safety & Tolerability Prescribing Information
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Dose Adjustments1​​​​​​​Dosing adjustments for renal impairment1
  • For moderate renal impairment (eGFR ≥30 to <60 mL/min), the dose of PAXLOVID should be reduced to 1 nirmatrelvir tablet and 1 ritonavir tablet, twice daily for 5 days.
For 5 consecutive days1 Morning Dose
  • One pink 150-mg tablet of nirmatrelvir
  • One white 100-mg tablet of ritonavir

Patients should take both tablets together.

 Evening Dose
  • One pink 150-mg tablet of 
    nirmatrelvir
  • One white 100-mg tablet of ritonavir

Patients should take both tablets together.

  • No dose adjustment of PAXLOVID is required for patients with mild renal impairment (eGFR ≥60 to <90 mL/min)​​​​​​​
  • PAXLOVID is not recommended in patients with severe renal impairment (eGFR <30 mL/min)
Dosing adjustments for mild or moderate hepatic impairment1
  • No dose adjustment of PAXLOVID is required for patients with either mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment
  • PAXLOVID is not recommended in patients with severe hepatic impairment​​​​​​​
EXPLORE MOREEfficacy & trial design

Discover the efficacy data and trial design of EPIC-HR. 

 Efficacy Loading Trial design LoadingReference:
  1. PAXLOVID Summary of Product Characteristics. https://www.medicines.ie/medicines/paxlovid-150-mg-100-mg-film-coated-tablets-35210/spc (Accessed October 2023).
Dosing Drug Interaction Finder

Easily search for drug interactions by active substance name or keywords.

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▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.

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Further information is available upon request

PP-PAX-IRL-0172. October 2023

Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
 

Adverse events should also be reported to Pfizer Medical Information on 1800 633 363

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PP-UNP-IRL-0832. October 2024
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PP-UNP-IRL-0832. October 2024