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Study Design1L study design2L+ study designEfficacy1L overall efficacy1L CNS efficacy1L 36-month overall efficacy1L 36-month CNS efficacy2L+ efficacySafetyPooled Safety: all lines1L safety2L+ safetyDosing & Therapy ManagementDosingTherapy management
Prescribing Information 

The information on this website is based on data from adult patients with ALK-positive advanced NSCLC (anaplastic lymphoma kinase positive advanced non small cell lung cancer) treated with LORVIQUA▼(lorlatinib), produced in line with the LORVIQUA (lorlatinib) Summary of Product Characteristics.
LORVIQUA (lorlatinib) Prescribing Information click here.
▼LORVIQUA is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 for how to report adverse reactions. Adverse event reporting information can also be found at the bottom of the page.

Meet ALK+ advanced NSCLC head on with LORVIQUA

LORVIQUA has shown durable benefit, both in previously treated and treatment naïve, ALK+ advanced NSCLC patients with or without brain metastases.1,2,5

Consider LORVIQUA as a first-line option for patients with ALK+ advanced NSCLC with or without brain metastases at baseline1,2

  • LORVIQUA demonstrated a significant improvement in PFS vs crizotinib, in patients with or without brain metastases1
  • LORVIQUA was designed to cross the blood barrier and has shown improved intracranial activity, suggetsing a protective effect against brain metastases. 2,3,4,5
  • LORVIQUA has a generally manageable safety profile with largely mild-to-moderate adverse reactions.1,2
  • However grade 3 and 4 ADRs, including Hypercholesterolaemia and hypertriglyceridemia, mean that LORVIQUA is subject to additional monitoring.1,2,5


Indications
  • LORVIQUA as monotherapy is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC) previously not treated with an ALK inhibitor.1
  • LORVIQUA as monotherapy is indicated for the treatment of adult patients with ALK-positive advanced NSCLC whose disease has progressed after:
    • alectinib or ceritinib as the first ALK tyrosine kinase inhibitor (TKI) therapy; or
    • crizotinib and at least one other ALK TKl.1
LORVIQUA efficacy
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LORVIQUA safety profile
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Therapy management
  See the strategies LoadingALK=anaplastic lymphoma kinase; NSCLC=non-small cell lung cancer; CNS=central nervous system; PFS=progression-free survival.ReferencesReferences:LORVIQUA  Summary of Product Characteristics. Solomon BJ, Besse B, Bauer TM, et al. Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study. Lancet Oncol. 2018;19(12):1654-1667.Shaw AT, Bauer TM, de Marinis F, et al; CROWN Trial Investigators. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. N Engl J Med. 2020;383(21):2018-2029.Johnson TW, Richardson PF, Bailey S, et al. Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]­benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. J Med Chem. 2014;57(11):4720-4744.Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study. Solomon, Bauer et al. Lancet Respir Med 2023;11(4):354-366
PP-LOR-IRL-0093 February 2024 Legal Category S1A Further information available on request

Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
 

Adverse events should also be reported to Pfizer Medical Information on 1800 633 363

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